Bromazine

Bromazine, sold under the brand names Ambodryl, Ambrodil, and Deserol among others, also known as bromodiphenhydramine, is an antihistamine and anticholinergic medication of the ethanolamine class. It is an analogue of diphenhydramine with a bromine substitution on one of the phenyl rings.

Grignard reaction between phenylmagnesium bromide and para-bromobenzaldehyde [1122-91-4] (1) gives p-bromobenzhydrol [29334-16-5] (2). Halogenation with acetyl bromide in benzene solvent gives p-bromo-benzhydrylbromide [18066-89-2] (3). Finally, etherification with deanol completed the synthesis of Bromazine (4).

Continuous and/or cumulative use of anticholinergic medications, including first-generation antihistamines, is associated with higher risk for cognitive decline and dementia in elderly people.

1. Antihistamine
2. Histamine
3. Quetiapine
4. Aripiprazole
5. Dimenhydrinate
6. Betahistine
7. Cyclobenzaprine
8. Brexpiprazole
9. Promethazine
10. H1 antagonist
11. Meclizine
12. Fexofenadine
13. Cariprazine
14. Amitriptyline
15. Trazodone
16. Diphenhydramine
17. Olanzapine
18. Famotidine
19. Risperidone
20. Loratadine