Alpha-2A adrenergic receptor

The alpha-2A adrenergic receptor (α_2A adrenoceptor), also known as ADRA2A, is an α₂ adrenergic receptor, and also denotes the human gene encoding it.

Receptor

α₂ adrenergic receptors include 3 highly homologous subtypes: α_2A, α_2B, and α_2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mice revealed that both the α_2A and α_2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the α_2A subtype inhibited transmitter release at high stimulation frequencies, whereas the α_2C subtype modulated neurotransmission at lower levels of nerve activity

Gene

This gene encodes α_2A subtype and it contains no introns in either its coding or untranslated sequences.

Ligands

Agonists

• 4-NEMD
• Brimonidine
• Clonidine
• Detomidine
• Dexmedetomidine
• Guanfacine
• Lofexidine
• Myrcene
• Medetomidine
• PS75
• Tizanidine
• Xylazine

Antagonists

• Atipamezole
• Idazoxan
• 1-PP (active metabolite of buspirone and gepirone)
• Asenapine
• BRL-44408
• Clozapine
• Lurasidone
• Mianserin
• Mirtazapine
• Paliperidone
• Risperidone
• Yohimbine

See also

• Adrenergic receptor

References

External links

• "α_2A-adrenoceptor". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2015-04-02. Retrieved 2008-11-25.
• Human ADRA2A genome location and ADRA2A gene details page in the UCSC Genome Browser.
• Human ZNF32 genome location and ZNF32 gene details page in the UCSC Genome Browser.

Further reading