Arrestin beta 1

Arrestin, beta 1, also known as ARRB1, is a protein which in humans is encoded by the ARRB1 gene.

Function

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known. Beta-arrestin has been shown to play a role as a scaffold that binds intermediates and may direct G-protein signaling by connecting receptors to clathrin-mediated endocytosis.

Interactions

Arrestin beta 1 has been shown to interact with

• Arf6,
• PTHLH,
• DVL2
• Mdm2,
• OPRD1,
• PSCD2, and
• RALGDS.

References

Further reading

External links

• Human ARRB1 genome location and ARRB1 gene details page in the UCSC Genome Browser.

1. Arrestin
2. Arrestin beta 2
3. G protein-coupled receptor kinase 2
4. Μ-opioid receptor
5. Alpha Arrestin
6. Parathyroid hormone-related protein
7. Beta-1 adrenergic receptor
8. G protein-coupled receptor kinase 3
9. Rod cell
10. Beta-2 adrenergic receptor
11. CYTH2
12. Visual phototransduction
13. DVL2
14. Glucagon-like peptide-1 receptor
15. Prostaglandin DP2 receptor
16. G protein-coupled receptor kinase
17. G protein-coupled receptor
18. Rhodopsin kinase
19. 25N-N1-Nap
20. RALGDS