PLAT domain

In molecular biology the PLAT domain is a protein domain that is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase Pfam PF01114, which mediates membrane association.

This domain forms a beta-sandwich composed of two β-sheets of four β-strands each.

Human proteins containing this domain

ALOX12; ALOX12B; ALOX12P2; ALOX15; ALOX15B; ALOX5; ALOXE3; LIPC; LIPG; LOXHD1; LPL; PKD1; PKD1L1; PKD1L2; PKD1L3; PKDREJ; PNLIP; PNLIPRP1; PNLIPRP2; PNLIPRP3; RAB6IP1;

References

1. Zinc-dependent phospholipase C
2. Arachidonate 5-lipoxygenase
3. Tissue-type plasminogen activator
4. Clostridium perfringens alpha toxin
5. Lipoxygenase
6. Hugh Plat
7. Kringle domain
8. EGF-like domain
9. Fibronectin type I domain
10. Joseph ibn Plat
11. LOXHD1
12. PKD1L1
13. Fibronectin type II domain
14. France
15. Neoplatonism
16. List of apple cultivars
17. Gawler Craton
18. Public Land Survey System
19. Estates General (France)
20. Chain (unit)