Arthur Ponsonby, 1st Baron Ponsonby of Shulbrede (1871–1946), British politician, writer, and social activist
Arthur Ponsonby, 11th Earl of Bessborough (1912–2002), British peer
Ashley Ponsonby DL, JP (1831–1898), British Liberal politician
Bernard Ponsonby, Scottish broadcast journalist
Brabazon Ponsonby, 1st Earl of Bessborough (1679–1758), British politician and peer
Lady Caroline Ponsonby (1785–1828), married name Lady Caroline Lamb, novelist and the lover of Lord Byron
Cecil Ponsonby (1889–1945), English cricketer, right-handed batsman and wicket-keeper
Chambré Brabazon Ponsonby (1720–1762), Irish Member of Parliament
Chambré Brabazon Ponsonby-Barker (1762–1834), Irish Member of Parliament
Charles Ponsonby, 2nd Baron de Mauley of Canford (1815–1896), British peer and Liberal politician
Sir Charles Ponsonby, 1st Baronet (1879–1976), British Conservative politician, Member of Parliament 1935–1950, created 1st Baronet Ponsonby, of Wootton, in 1956
Edward Ponsonby, 8th Earl of Bessborough, KP, CB, CVO (1851–1920), British peer
Elizabeth Ponsonby, a prominent member of the Bright Young Things in the 1920s, daughter of Arthur Ponsonby, 1st Baron Ponsonby of Shulbrede
Frederick Ponsonby, 10th Earl of Bessborough (1913–1993), British diplomat, businessman, playwright, Conservative politician and peer
Frederick Ponsonby, 1st Baron Sysonby GCB GCVO PC (1867–1935), British soldier and courtier
Frederick Ponsonby, 3rd Earl of Bessborough (1758–1844), British peer
Frederick Ponsonby, 4th Baron Ponsonby of Shulbrede (born 1958), British peer and Labour politician
Frederick Ponsonby, 6th Earl of Bessborough (1815–1895), a founder of Surrey County Cricket Club and I Zingari
Frederick Ponsonby, 1st Baron Sysonby (1867–1935), British politician
Major-General Sir Frederick Cavendish Ponsonby (1783–1837), British military officer
George Ponsonby (Junior Lord of the Treasury) (1773–1863), Irish politician
George Ponsonby (1755–1817), Lord Chancellor of Ireland
Henrietta Ponsonby, Countess of Bessborough (1761–1821), wife of Frederick Ponsonby, 3rd Earl of Bessborough, mother of Lady Caroline Lamb
Henry Ponsonby (died 1745) (1685–1745), Irish soldier
Sir Henry Ponsonby (1825–1895), Private Secretary to Queen Victoria
Jack Ponsonby (1874–1962), Irish footballer
John Ponsonby (British Army officer) (1866–1952), commanded 5th Division during World War I
Hon. John Ponsonby (politician) (1713–1789), Speaker of the Irish House of Commons
John Ponsonby, 4th Earl of Bessborough (1781–1847), British politician and Lord Lieutenant of Ireland
John Ponsonby, 5th Earl of Bessborough (1809–1880), British peer and politician
John Ponsonby, 1st Viscount Ponsonby of Imokilly, (c.1772–1855), British diplomat
John Ponsonby (RAF officer), Air Vice-Marshal
Loelia Ponsonby (married name Loelia Lindsay) (1902–1993), British peeress, needlewoman and magazine editor
Myles Ponsonby CBE (1924–1999), British soldier, intelligence officer, diplomat and politician
The Rt. Rev. Richard Ponsonby (1722–1815), Bishop of Derry and Raphoe
Roberte Ponsonby, Countess of Bessborough (1892–1979), the daughter of Baron Jean de Neuflize, CVO
Rupert Ponsonby, 7th Baron de Mauley (born 1957), British peer