5-Fluoro-DMT

5-Fluoro-N,N-dimethyltryptamine (5-fluoro-DMT, 5F-DMT) is a tryptamine derivative related to compounds such as 5-bromo-DMT and 5-MeO-DMT. Fluorination of psychedelic tryptamines either reduces or has little effect on 5-HT_2A/C receptor affinity or intrinsic activity, although 6-fluoro-DET is inactive as a psychedelic despite acting as a 5-HT_2A agonist (cf. lisuride), while 4-fluoro-5-methoxy-DMT is a much stronger agonist at 5-HT_1A than 5-HT_2A.

See also

• 5-Fluoro-AMT
• 5-Fluoro-DET
• 5-Fluoro-MET
• 6-fluoro-AMT
• 6-Fluoro-DMT
• 4-fluoro-5-methoxy-DMT
• 6-Fluoro-DET(6-Fluoro-DET)
• O-4310
• It's worth noting that GR-159897 is based on the same structure.

References