Homoquinolinic acid

Homoquinolinic acid (HQA) is a potent excitotoxin which is a conformationally-restricted analogue of N-methyl-D-aspartate (NMDA) and a partial agonist of the main/glutamate site of the NMDA receptor, with some selectivity for NR2B subunit-containing receptors. It is approximately equipotent to NMDA and about five times more potent than quinolinic acid as an agonist of the NMDA receptor. HQA has also been found to label a novel, yet uncharacterized binding site, which can be distinguished from the NMDA receptor with the use of 2-carboxy-3-carboxymethylquinoline (CCMQ), a selective ligand of the uncharacterized site.

See also

• Aspartate
• Ibotenic acid
• Tetrazolylglycine

References

1. Glutamic acid
2. Alanine
3. Muscimol
4. Aspartic acid
5. Glycine
6. Fluorexetamine
7. Kainate receptor
8. Glutathione
9. Piracetam
10. N-Methyl-D-aspartic acid
11. Quinolinic acid
12. Ibotenic acid
13. Saffron
14. Hydrochlorothiazide
15. Deoxymethoxetamine
16. 5,7-Dichlorokynurenic acid
17. Pentobarbital
18. Magnesium
19. Spermidine
20. Aniracetam