Apolipoprotein C-II

Apolipoprotein C-II (Apo-CII, or Apoc-II), or apolipoprotein C2 is a protein that in humans is encoded by the APOC2 gene.

The protein encoded by this gene is secreted in plasma, where it is a component of very low density lipoproteins and chylomicrons. This protein activates the enzyme lipoprotein lipase in capillaries, which hydrolyzes triglycerides and thus provides free fatty acids and glycerols for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by xanthomas, pancreatitis, and hepatosplenomegaly, but no increased risk for atherosclerosis. Lab tests will show elevated blood levels of triglycerides, cholesterol, and chylomicrons

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.

See also

• Apolipoprotein C

References

External links

• Human APOC2 genome location and APOC2 gene details page in the UCSC Genome Browser.

1. Apolipoprotein
2. Hyperlipidemia
3. Apolipoprotein A-II
4. Apolipoprotein C
5. Apolipoprotein C-III
6. Lipoprotein
7. Apolipoprotein C-I
8. Apolipoprotein AI
9. Very low-density lipoprotein
10. Lipoprotein lipase
11. Chylomicron
12. Amyloidosis
13. Amyloid
14. Apolipoprotein C-IV
15. List of diseases (A)
16. C-reactive protein
17. C2
18. Apolipoprotein D
19. APOM
20. Vitellogenin