Beta-Hydroxy beta-methylbutyryl-CoA

β-Hydroxy β-methylbutyryl-coenzyme A (HMB-CoA), also known as 3-hydroxyisovaleryl-CoA, is a metabolite of L-leucine that is produced in the human body. Its immediate precursors are β-hydroxy β-methylbutyric acid (HMB) and β-methylcrotonoyl-CoA (MC-CoA). It can be metabolized into HMB, MC-CoA, and HMG-CoA in humans.

Metabolic pathway

Notes

References

1. Β-Hydroxy β-methylbutyric acid
2. HMG-CoA
3. Acetoacetyl-CoA
4. Β-Hydroxybutyryl-CoA
5. Propionyl-CoA
6. Succinyl-CoA
7. Α-Ketoisocaproic acid
8. 3-Methylglutaconyl-CoA
9. Β-Ketoisocaproic acid
10. 3-Hydroxyisobutyric acid
11. Leucine
12. Β-Leucine
13. Methylcrotonyl-CoA
14. Branched-chain alpha-keto acid dehydrogenase complex
15. Isovaleryl-CoA
16. Oxaloacetic acid
17. Threonine
18. 4-Maleylacetoacetic acid
19. Tryptophan
20. Proline