Substituted piperazine

Substituted piperazines are a class of chemical compounds based on a piperazine core. Some are used as recreational drugs and some are used in scientific research.

List of substituted piperazines

Benzylpiperazines

Phenylpiperazines

ortho-Substituted

• 2-Chlorophenylpiperazine (oCPP)
• 2-Methylphenylpiperazine (oMPP)
• 2-Methoxyphenylpiperazine (oMeOPP)
• Vortioxetine

Enpiprazole is known to produce oCPP as a metabolite.

Enciprazine was initially anticipated to produce oMeOPP as a metabolite, but this turned out not to be the case.

meta-Substituted

• 3-Chlorophenylpiperazine (mCPP)
• 3-Methoxyphenylpiperazine (mMeOPP)
• 3-Trifluoromethylphenylpiperazine (TFMPP)
• 1-(3-Chlorophenyl)-4-(2-phenylethyl)piperazine (3C-PEP)

Trazodone, nefazodone, mepiprazole, and others produce mCPP as a metabolite.

para-Substituted

• 4-Chlorophenylpiperazine (pCPP)
• 4-Fluorophenylpiperazine (pFPP)
• 4-Methylphenylpiperazine (pMPP)
• 4-Methoxyphenylpiperazine (MeOPP)
• 4-Nitrophenylpiperazine (pNPP)
• 4-Trifluoromethylphenylpiperazine (pTFMPP)

Multiple substitutions

• 2,3-Methylphenylpiperazine (DMPP)
• 3-Trifluoromethyl-4-chlorophenylpiperazine (TFMCPP)

Others

• 1-Phenylpiperazine (PP)

Other arylpiperazines

• 1-(1-Naphthyl)piperazine (1-NP)
• 1-(2-Pyrimidinyl)piperazine (1-PP)
• ORG-12962 (1-(5-trifluoromethyl-6-chloropyridin-2-yl)piperazine)
• Quipazine (2-piperazin-1-ylquinoline)

Many azapirones such as buspirone, gepirone, and tandospirone produce 1-PP as a metabolite.

See also

• Substituted α-alkyltryptamine
• Substituted amphetamine
• Substituted cathinone
• Substituted methylenedioxyphenethylamine
• Substituted phenethylamine
• Substituted phenylmorpholine
• Substituted tryptamine

References

1. Piperazine
2. Trifluoromethylphenylpiperazine
3. Pyrimidinylpiperazine
4. 1-(3-Chlorophenyl)-4-(2-phenylethyl)piperazine
5. Substituted phenethylamine
6. Meta-Chlorophenylpiperazine
7. Substituted cathinone
8. Methylenedioxybenzylpiperazine
9. Benzylpiperazine
10. Phenylpiperazine
11. 2,3-Dichlorophenylpiperazine
12. Para-Methoxyphenylpiperazine
13. Substituted amphetamine
14. CM156
15. 1-(4-(Trifluoromethyl)phenyl)piperazine
16. Sigma receptor
17. 2C-B-PP
18. Para-Chlorophenylpiperazine
19. 2C-B-BZP
20. Naphthylpiperazine