The knockout stage of the 2021 Copa América began on 2 July 2021 with the quarter-finals and ended on 10 July 2021 with the final at the Estádio do Maracanã in Rio de Janeiro.
Originally, the knockout stage was scheduled to be played from 4 to 12 July 2020. However, on 17 March 2020 the tournament was postponed until 2021 due to the COVID-19 pandemic in South America.
All match times listed are in BRT (UTC−3).
In the knockout stage, if a match was tied after 90 minutes:
The top four placed teams from each group qualified for the knockout stage.
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