Vinyl sulfone

In organic chemistry, a vinyl sulfone is a functional group consisting of a vinyl group bonded to a sulfone group. Specific compounds containing this functional group are divinyl sulfone, phenyl vinyl sulfone, methyl vinyl sulfone, and ethyl vinyl sulfone.

The sulfone makes the vinyl group electrophilic, allowing it to be used as a pharmacophore for binding to the thiol of cysteine residues. This same reactive nature is responsible for their major industrial use in vinyl sulfone dyes.

Uses

Vinyl sulfone has uses as a molluscicide pesticide.

Phenyl vinyl sulfone has been applied to ruthenium chemistry as part of olefin metathesis reactions.

Vinyl sulfone has applications to protein purification, especially when linked with mercaptoethanol.

References

1. Vinyl sulfone dyes
2. Sulfone
3. Vinyl group
4. Reactive dye
5. Discharge printing
6. Resist dyeing
7. Copper(II) chloride
8. Divinyl sulfide
9. Anionic addition polymerization
10. Lucifer yellow
11. Cathepsin K
12. Sulfolene
13. Desulfonylation reactions
14. MoOPH
15. Febrifugine
16. Cathepsin L2
17. Cathepsin S
18. Ammonium iodide
19. Vinyl iodide functional group
20. PEGylation