Lottie Williams (actress, born 1866) (1866–1929), American actress
Lottie Williams (actress, born 1874) (1874–1962), American actress
Lottie Williams, an Oklahoma resident who is the only person to have been struck by re-entering space debris, when a small piece of the rocket launching the Midcourse Space Experiment harmlessly struck her shoulder in 1997
Lottie Williams, a victim of a 1980 murder for which Leonard Marvin Laws was executed by the U.S. state of Missouri in 1990