Sicilia is a surname. Notable people with the surname include:
Gina Sicilia (born 1985), American singer, songwriter, and musician
Gustavo Sáenz de Sicilia (1885 – 1950), a Mexican silent film director, producer, journalist, civil engineer, and founder of Compañía Nacional Productora de Películas
Horacio Sicilia (born 1974), Argentine rower
Javier Sicilia (born 1956), Mexican poet, essayist, novelist, peace activist and journalist
Joan Enric Vives i Sicília (born 1949), Spanish cleric
Joan Francesc Ferrer Sicilia (born 1970), Spanish former footballer
José María Sicilia (born 1954), Spanish abstractionist painter
Nina Sicilia (born 1962), Venezuelan model and beauty queen
Pablo Sicilia (born 1981), Spanish former footballer
Sam Sicilia (born 1986), American professional mixed martial artist