2-Aminooxazole

2-Aminooxazole is a heterocyclic organic compound, belonging to the class of oxazoles. It is a five-membered ring structure containing one oxygen and two nitrogen atoms.

Properties

2-Aminooxazole contains a primary amine group which can participate in various reactions like protonation, acylation, or alkylation. The oxazole ring can also show reactions like ring expansion, electrophilic substitution, etc. and also contributes aromatic character and stability to the molecule.

Applications

2-Aminooxazole possesses antimicrobial properties against various fungal and bacterial strains especially against Tuberculosis-causing Mycobacterium tuberculosis.

The amine group of 2-Aminooxazole can potentially link with different molecules, making it a potential candidate for drug synthesis in antitubercular medicinal chemistry.

2-Aminooxazole has also been hypothesised to have played a role in chemical evolution as a precursor of RNA nucleotides.

See also

• Oxazoles
• 2-Aminothiazole

References

1. Cyanosulfidic prebiotic synthesis
2. C3H4N2O
3. John Sutherland (chemist)