5-Fluoro-MET

5-Fluoro-MET (5F-MET, 5-fluoro-N-methyl-N-ethyltryptamine) is a psychedelic tryptamine derivative related to drugs such as 5-Fluoro-DMT and N-Methyl-N-ethyltryptamine (MET). It acts as an agonist at the 5-HT_2A receptor with an EC₅₀ of 20.6 nM and produces a head-twitch response in animal studies. Ring fluorination in this case increases efficacy at 5-HT_2A, with 5F-MET having an efficacy of 87.6% vs 5-HT, vs 36.2% for the partial agonist MET. It is claimed to have antidepressant activity.

See also

• 5-Fluoro-AMT
• 5-Fluoro-AET
• 5-Fluoro-DET
• 5-Fluoro-EPT
• 5-MeO-MET
• 7-F-5-MeO-MET

References

1. 5-Fluoro-DMT
2. 5-Fluoro-AET
3. 5-MeO-MET
4. 5-Fluoro-EPT
5. 5-Fluoro-AMT
6. 7-F-5-MeO-MET
7. 5-Fluoro-DET
8. Substituted tryptamine
9. 4-Fluoro-5-methoxy-DMT
10. O-4310
11. 6-Fluoro-DET
12. 7-Chloro-AMT
13. List of designer drugs
14. 5-TFM-DMT
15. 5-Chloro-αMT
16. 5-Bromo-DMT
17. List of psychedelic drugs
18. 5-TFMO-DMT
19. Psilocin
20. 5-MeO-EPT